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Antigenic Specificity | DBNL |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 131-430 of human DBNL (NP 001014436.1). |
Other Names | [ABP1; HIP55; SH3P7; HIP-55] |
Gene, Accession # | [DBNL], Gene ID: 28988, NCBI: Q9UJU6.1, UniProt: Q9UJU6 |
Catalog # | MBS8549207 |
Price | $280 |
Order / More Info | DBNL Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |