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Antigenic Specificity | b-Amyloid 1-40, 42, CT |
Clone | [6D4] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | purified |
Size | 0.1 mg |
Concentration | 0.1mg/ml |
Applications | ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC). Other applications have not been tested. |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes human C-terminal b-amyloid (aa1-40 and aa1-42). Crossreactivity: APP. The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, respectively, and the retentionof corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P# peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/ nicastrin-mediated gamma-secretase processing of C99 releases the amylo |
Immunogen | Immunogen: Synthetic peptide corresponding to aa1-40 and aa1-42 of C-terminal human b-amyloid, conjugated to KLH. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS603141 |
Price | $730 |
Order / More Info | b-Amyloid 1-40, 42, CT Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |