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Antigenic Specificity | FLNB |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Filamins are a family of dimeric actin binding proteins that function as structural components of cell adhesion sites. They also serve as a scaffold for subcellular targeting of signaling molecules (1). The actin binding domain (alpha-actinin domain) located at the amino terminus is followed by as many as 24 tandem repeats of about 96 residues and the dimerization domain is located at the carboxy terminus. In addition to actin filaments, filamins associate with other structural and signaling molecules such as beta integrins, Rho/Rac/Cdc42, PKC, and the insulin receptor, primarily through the carboxy-terminal dimerization domain (1-3). Filamin A, the most abundant, and filamin B are widely expressed isoforms, while filamin C is predominantly |
Immunogen | Immunogen: A synthetic peptide of human FLNB Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [ABP-278; AOI; DKFZp686A1668; DKFZp686O033; FH1; FLN1L; LRS1; SCT; TABP; TAP] |
Gene, Accession # | [FLNB], Gene ID: 2317, NCBI: NP_001157789.1, UniProt: O75369 |
Catalog # | MBS8503495 |
Price | $310 |
Order / More Info | FLNB Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Stossel, T. P. et al. (2001) Nat. Rev. Mol. Cell Biol. 2, 138-145. 2. Tigges, U. et al. (2003) J. Biol. Chem. 278, 23561-23569. 3. He, H. et al. (2003) J. Biol. Chem. 278, 27096-27104. 4. Vadlamudi, R. K. et al. (2002) Nat. Cell Biol. 4, 681-690. |