Edit |   |
---|---|
Antigenic Specificity | CaMK2alpha/beta/delta (Phospho-Thr305) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of CaMKII only when phosphorylated at threonine 305. Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which ena |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of threonine 305 (I-L-T(p)-T-M) derived from Human CaMK2a/b/d. |
Other Names | [CaMK2a/b/d (Phospho-Thr305); CAMK2A; KCC2A; kinase CaMK2-alpha; CaMKII-alpha] |
Gene, Accession # | [CaMK2alpha/beta/delta], Gene ID: 815, NCBI: NP_741960.1, UniProt: Q9UQM7 |
Catalog # | MBS9401983 |
Price | $200, $255 |
Order / More Info | CaMK2alpha/beta/delta (Phospho-Thr305) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |