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Antigenic Specificity | Phospho-CREB1-S133 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34. It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories. |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S133 of human CREB1 Calculated Molecular Weight: 43kDa |
Other Names | [Phospho-CREB1-S133: CREB-1; CREB1], [CREB1; CREB1; CREB; CREB-1; cAMP-responsive element-binding protein 1] |
Gene, Accession # | [CREB1], Gene ID: 1385, NCBI: P16220.2, UniProt: P16220 |
Catalog # | MBS128455 |
Price | $235, $350, $525 |
Order / More Info | Phospho-CREB1-S133 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |