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Antigenic Specificity | DNA Polymerase alpha |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total DNA Polymerase a protein. Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from N-terminal of human DNA Polymerase a. |
Other Names | [DNA Polymerase a; DNA pol alpha; DNA polymerase alpha catalytic subunit; DPOA; DPOLA; EC 2.7.7.7] |
Gene, Accession # | Gene ID: 5422, NCBI: NP_058633.2, UniProt: P09884 |
Catalog # | MBS9413092 |
Price | $200, $255 |
Order / More Info | DNA Polymerase alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |