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Antigenic Specificity | ANXA5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Annexin V, also known as PAP-1 or Lipocortin V, is a ~30 kDa protein that binds to phospholipids in a calcium-dependent manner (1). All annexins contain a putative PKC binding site, but only annexin V has been identified as an inhibitor of this pathway (2). It may also signal, by direct interaction with VEGFR2 receptor, in the regulation of vascular endothelial cell proliferation (3). Annexin V preferentially binds phosphatidylserine, in competition with prothrombin, leading to inhibition of blood coagulation at sites of injury preceding contact between lipid components and coagulation factors that initiate thrombosis (4-6). The ability of Annexin V to bind specifically and robustly to hosphatidylserine makes it an attractive reagent in det |
Immunogen | Immunogen: Recombinant protein of human ANXA5 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [ANX5; ENX2; PP4] |
Gene, Accession # | [ANXA5], Gene ID: 308, NCBI: NP_001145.1, UniProt: P08758 |
Catalog # | MBS8504275 |
Price | $310 |
Order / More Info | ANXA5 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Huber, R. et al. (1990) EMBO J 9, 3867-74. 2. Cardo-Vila, M. et al. (2003) Mol Cell 11, 1151-62. 3. Wen, Y. et al. (1999) Biochem Biophys Res Commun 258, 713-21. 4. Koopman, G. et al. (1994) Blood 84, 1415-20. 5. London, F. et al. (1996) Biochemistry 35, 16886-97. 6. Thiagarajan, P. and Benedict, C.R. (1997) Circulation 96, 2339-47. 7. Vermes, I. et al. (1995) J Immunol Methods 184, 39-51. 8. Grundmann, U. et al. (1988) Proc Natl Acad Sci USA 85, 3708-12. |