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Antigenic Specificity | NALP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1. Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis. NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli. Multiple alternatively spliced transcript variants encoding dist |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a peptide corresponding to 13 amino acids near the carboxy terminus of human NALP1. |
Other Names | [CARD7, DEFCAP, NACHT domain-leucine-rich-repeat and PYD-containing protein 1] |
Gene, Accession # | [NALP1], Gene ID: 22861, NCBI: AAG30288 |
Catalog # | MBS9410009 |
Price | $320 |
Order / More Info | NALP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |