Edit |   |
---|---|
Antigenic Specificity | Bcl-6 (Follicular Lymphoma Marker) |
Clone | [BCL6/1951R] |
Host Species | Rabbit |
Reactive Species | human. |
Isotype | IgG |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 po |
Immunogen | Immunogen: Recombinant fragment of human bcl-6 protein (around aa 256-389) Cellular Localization: Nuclear |
Other Names | [B-cell lymphoma 5 protein; B-Cell Lymphoma 6 Protein; BCL5; BCL6; BCL6A; cys his2 zinc finger transcription factor; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S] |
Gene, Accession # | [Bcl-6], Gene ID: 604, NCBI: NP_001124317.1, UniProt: P41182 |
Catalog # | MBS4380213 |
Price | $190, $340, $340 |
Order / More Info | Bcl-6 (Follicular Lymphoma Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Ree, H.J., et al. 2003. Hum. Pathol. 34: 610-616. Pasqualucci, L., et al. 2003. Leuk. Lymphoma 44 Suppl 3: S5-12. Garcia JF, et al.2006.J. Histochem Cytochem.54:31. |