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Antigenic Specificity | PSEN2 - middle region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively sp |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse PSEN2 |
Other Names | [presenilin-2; Presenilin-2; presenilin-2; presenilin 2] |
Gene, Accession # | [PSEN2], Gene ID: 19165, NCBI: NP_001122077.1, UniProt: Q61144 |
Catalog # | MBS3224155 |
Price | $335 |
Order / More Info | PSEN2 - middle region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |