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Antigenic Specificity | Bid |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 500 ug/ml |
Applications | Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Bid, a BH3 domain containing proapoptotic Bcl 2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces Cytochrome C release and mitochondrial damage. The Cytochrome C releasing activity of Bid was antagonized by Bcl 2. Mutation in the SH3 domain can diminish the Cytochrome C releasing activity. In the animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas. |
Immunogen | Immunogen: Bid antibody was raised in Rabbit using synthetic peptide surrounding amino acid 37 of human Bid as the immunogen. |
Other Names | [Rabbit Bid; Bid; Bid] |
Gene, Accession # | [Bid] |
Catalog # | MBS5309071 |
Price | $705 |
Order / More Info | Bid Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |