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Antigenic Specificity | BECN1 |
Clone | [AT45E8] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b, k |
Format | Protein A purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1 mg/ml |
Applications | ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene (Atg) 6 and BEC-1 in the C. elegans nematode. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. |
Immunogen | Immunogen: Recombinant human BECN (1-450aa) purified from E. coli |
Other Names | [beclin 1; ATG6; beclin1; VPS30], [BECN1; BECN1; ATG6; VPS30; beclin1; GT197] |
Gene, Accession # | [BECN1], Gene ID: 8678, NCBI: NP_003757, UniProt: Q14457 |
Catalog # | MBS200344 |
Price | $240, $315 |
Order / More Info | BECN1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Liang XH., et al. (1998) J Virol. 72 (11): 8586-8596.; Takacs-Vellai K., et al. (2005) Curr Biol. 15 (16): 1513-1517. |