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Antigenic Specificity | Phospho-FOS-T232 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The Fos family of nuclear oncogenes includes c-Fos, FosB, Fos-related antigen 1 (FRA1), and Fos-related antigen 2 (FRA2) (1). While most Fos proteins exist as a single isoform, the FosB protein exists as two isoforms: full-length FosB and a shorter form, FosB2 (Delta FosB), that lacks the carboxy-terminal 101 amino acids (1-3). The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator Protein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-z |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding T232 of human FOS Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [p55; AP-1; C-FOS] |
Gene, Accession # | [FOS-T232], Gene ID: 2353, NCBI: NP_005243.1, UniProt: P01100 |
Catalog # | MBS8527425 |
Price | $310 |
Order / More Info | Phospho-FOS-T232 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Tulchinsky, E. (2000) Histol. Histopathol. 15, 921-928. 2. Dobrzanski, P. et al. (1991) Mol. Cell. Biol. 11, 5470-5478. 3. Nakabeppu, Y. and Nathans, D. (1991) Cell 64, 751-759. 4. Rosenberger, S.F. et al. (1999) J. Biol. Chem. 274, 1124-1130. 5. Sasaki, T. et al. (2006) Mol. Cell 24, 63-75. 6. Basbous, J. et al. (2007) Mol. Cell. Biol. 27, 3936-3950. 7. Kovary, K. and Bravo, R. (1991) Mol. Cell. Biol. 11, 2451-2459. 8. Kovary, K. and Bravo, R. (1992) Mol. Cell. Biol. 12, 5015-5023. |