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Antigenic Specificity | BACE1 (N-term), 38-70 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse (predicted reactivity: bovine, rat) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This BACE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-70 amino acids from the N-terminal region of human BACE1. Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. |
Immunogen | n/a |
Other Names | [Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2; BACE1; BACE; KIAA1149] |
Gene, Accession # | [BACE1], Gene ID: 23621, NCBI: NP_001193978.1, UniProt: P56817 |
Catalog # | MBS9206528 |
Price | $165, $370 |
Order / More Info | BACE1 (N-term), 38-70 Antibody from MYBIOSOURCE INC. |
Product Specific References | Xie, J., et al., J. Biol. Chem. 280(14):13824-13832 (2005). He, X., et al., J. Biol. Chem. 280(12):11696-11703 (2005). Huang, X.P., et al., J. Biol. Chem. 279(36):37886-37894 (2004). Chiocco, M.J., et al., J. Biol. Chem. 279(50):52535-52542 (2004). Yang, H.C., et al., J. Neurochem. 91(6):1249-1259 (2004). |