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Antigenic Specificity | CLK2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total CLK2 protein. Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human CLK2. |
Other Names | [CDC-like kinase 2; EC 2.7.12.1; kinase CLK2] |
Gene, Accession # | [CLK2], Gene ID: 1196, NCBI: NP_001281267.1, UniProt: P49760 |
Catalog # | MBS9410144 |
Price | $200, $255 |
Order / More Info | CLK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |