Phospho-Bad (S99) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Bad (S99) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: mouse, rat) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Immunofluorescence (IF), Dot Blot (DB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Bad Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S99 of human Bad. Bad is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin are found to be involved in the regulation of this protein. Bad is phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, w |
| Immunogen | n/a |
| Other Names | [Bcl2-associated agonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; BAD; BBC6; BCL2L8] |
| Gene, Accession # | [BAD], Gene ID: 572, NCBI: NP_004313.1, UniProt: Q92934 |
| Catalog # | MBS9207687 |
| Price | $165, $370 |
| Order / More Info | Phospho-Bad (S99) Antibody from MYBIOSOURCE INC. |
| Product Specific References | References for protein: 1.Hurbin, A., et al., J. Biol. Chem. 280(20):19757-19767 (2005). 2.Antignani, A., et al., Biochemistry 44(10):4074-4082 (2005). 3.Ying, S., et al., Infect. Immun. 73(3):1399-1403 (2005). 4.Seo, S.Y., et al., J. Biol. Chem. 279(40):42240-42249 (2004). 5.Lee, J.W., et al., Carcinogenesis 25(8):1371-1376 (2004). References for HeLa cell line: 1. Scherer WF, Syverton JT, Gey GO (May 1953). Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix. J. Exp. Med. 97 (5): 695-710. [PubMed:13052828]. 2. Macville M, Schrock E, Padilla-Nash H, Keck C, Ghadimi BM, Zimonjic D, Popescu N, Ried T (January 1999). Comprehensive and definitive molecular cytogenetic characterization of HeLa cells by spectral karyotyping. Cancer Res. 59 (1): 141-50. [PubMed: 9892199]. 3. Rahbari R, Sheahan T, Modes V, Collier P, Macfarlane C, Badge RM (April 2009). A novel L1 retrotransposon marker for HeLa cell line identification. BioTechniques 46 (4): 277-84. [PubMed: 19450234]. 4. Capes-Davis A, Theodosopoulos G, Atkin I, Drexler HG, Kohara A, MacLeod RA, Masters JR, Nakamura Y, Reid YA, Reddel RR, Freshney RI (July 2010). Check your cultures. A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127 (1): 1-8. [PubMed:20143388]. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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