Dimethyl-Histone H3 (Lys 27) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Dimethyl-Histone H3 (Lys 27) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat, mouse, chicken, bovine |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mg |
| Concentration | Size: 100 ug/200 ul |
| Applications | ELISA, Western Blot, ChIP, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody only recognizes ~ 17 kDa of Dimethylated Histone H3 at K27. It does not cross react to nonmethylated H3 or mono-, Tri-methylated Histone H3. Histones are basic nuclear proteins that together with DNA make up the nucleosome structure in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The methylation of specific residues in the histone tails is a central modification for regulatingepigenetic transitions in chromatin. Whereas methylation of histone H3 on lysine 4, 36, and 79 has been linked with gene activation, methylation of H3 on lysines 9, 27 and histone H4 on lysine 20 is associated with heterochromatin |
| Immunogen | Antigen Preparation: A synthetic peptide containing AR[Me2-K]ST in which Me2-K corresponds to Dimethyl lysine 27 of human histone H3. |
| Other Names | n/a |
| Gene, Accession # | [Dimethyl-Histone H3 (Lys27)] |
| Catalog # | MBS462179 |
| Price | $285 |
| Order / More Info | Dimethyl-Histone H3 (Lys 27) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Vakoc C et al. Histone H3 Lysine 9 Methylation and HP1gamma Are Associated with Transcription Elongation through Mammalian Chromatin. Molecular Cell (2003), Volume 19, Issue 3, Pages 381 - 391. David J Seward, et al. Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nature Structural & Molecular Biology 14, 240 - 242 (2007) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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