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Antigenic Specificity | Caspase-12 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.2 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains two pathways, in which the key apoptotic proteases caspase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is located to the ER, but not to the cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium hemeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates |
Immunogen | Immunogen: Synthetic peptide corresponding to residues surrounding amino acid 310 of mouse caspase-12 |
Other Names | [CASP12; CASP12P1], [Casp12; Casp12; CASP-12] |
Gene, Accession # | Gene ID: 12364, NCBI: NP_033938.3 |
Catalog # | MBS841363 |
Price | $150, $330 |
Order / More Info | Caspase-12 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |