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Antigenic Specificity | CRTC1 |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene. t(11; 19) (q21; p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. |
Immunogen | Immunogen: Purified recombinant fragment of human CRTC1 expressed in E. Coli. |
Other Names | [MECT1; TORC1; WAMTP1; FLJ14027; KIAA0616; CRTC1], [CRTC1; CRTC1; MECT1; TORC1; TORC-1; WAMTP1; TORC-1; Transducer of CREB protein 1] |
Gene, Accession # | [CRTC1], Gene ID: 23373, NCBI: NP_001091952.1, UniProt: Q6UUV9 |
Catalog # | MBS850612 |
Price | $280 |
Order / More Info | CRTC1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |