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Antigenic Specificity | Phospho-BID (Ser78) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB); Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polyclonal antibody to detect endogenous levels of BID (pSer78) in human; mouse and rat samples. Bid; a BH3 domain-containing proapoptotic Bcl-2 family member; is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity; which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In the animal model studies; Bid-deficient mice are found resistant to the lethal effects of death factor signals r |
Immunogen | Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BID |
Other Names | [BH3-interacting domain death agonist; p22 BID; BID], [BID; BID; FP497; BID] |
Gene, Accession # | [BID], Gene ID: 637, NCBI: NP_001187.1, UniProt: P55957 |
Catalog # | MBS846030 |
Price | $375 |
Order / More Info | Phospho-BID (Ser78) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |