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Antigenic Specificity | EP300(S1834) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein A purified |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1807-1841 amino acids from human. Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone |
Immunogen | n/a |
Other Names | [Purified Rabbit (Pab); Histone acetyltransferase p300; p300 HAT; 2.3.1.48; E1A-associated protein p300; EP300; P300] |
Gene, Accession # | [EP300], Gene ID: 2033, NCBI: NP_001420.2, UniProt: Q09472 |
Catalog # | MBS9231237 |
Price | $165, $370 |
Order / More Info | EP300(S1834) Antibody from MYBIOSOURCE INC. |
Product Specific References | Eckner R.,et al.Genes Dev. 8:869-884(1994). Dunham I.,et al.Nature 402:489-495(1999). Mural R.J.,et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Chaffanet M.,et al.Genes Chromosomes Cancer 28:138-144(2000). Lundblad J.R.,et al.Nature 374:85-88(1995). |