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Antigenic Specificity | Human Junctional adhesion molecule C (JAM-C) |
Clone | [4M35] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Neutr |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Members of the junctional adhesion molecule (JAM) family are type I transmembrane glycoproteins of the immunoglobulin (Ig) superfamily that are localized in the tight junctions between endothelial or epithelial cells and appear to be involved in leukocyte transmigration. JAM-A, also known as platelet adhesion molecule 1 (PAM-1) and platelet F11 receptor, contains two V-type Ig-like domains, forms homodimers, and interacts with LFA-1. JAM-B (vasculoendothelial or VE-JAM) and JAM-C each contain two Ig domains (one V-type and one C2-type), a cytoplasmic PDZ-binding motif and a PKC phosphorylation site. JAM-C interacts with MAC-1 and facilitates JAM-B interaction with integrin alpha 4 beta 1. |
Immunogen | Antibody Generation: Monoclonal antibodies were produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with recombinant human JAM-C. This IgG1 antibody was purified from supernatant on a Protein G chromatography column. |
Other Names | [JAM3; JAMC; JAM-C], [JAM3; JAM3; JAMC; JAM-2; JAM-3; JAM-C; JAM-C; JAM-3] |
Gene, Accession # | [JAM-C], Gene ID: 83700, NCBI: NP_001192258.1, UniProt: Q9BX67 |
Catalog # | MBS690010 |
Price | $490 |
Order / More Info | Human Junctional adhesion molecule C (JAM-C) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |