Description | This CDK5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 225-260 amino acids from the C-terminal region of human CDK5. Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and p |
Product Specific References | Meyerson M.,et al.EMBO J. 11:2909-2917(1992). Meyerson M.,et al.Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases. Li Q.,et al.Mol. Biol. Rep. 37:2415-2421(2010). Hu X.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. |