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Antigenic Specificity | SOS1 |
Clone | [SOS-01] |
Host Species | Mouse |
Reactive Species | mouse |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | IgG concentration 1.0mg/ml |
Applications | ELISA (EIA), Immunofluorescence (IF), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mouse anti Human SOS1 antibody, clone SOS-1 recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (Hart et al. 2002), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features (Hanna et al. 2009). |
Immunogen | n/a |
Other Names | [son of sevenless homolog 1; Son of sevenless homolog 1; son of sevenless homolog 1; SOS-1; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; son of sevenless homolog 1 (Drosophila)], [SOS1; SOS1; GF1; HGF; NS4; GGF1; GINGF; SOS-1] |
Gene, Accession # | [SOS1], Gene ID: 6654, NCBI: NP_005624.2, UniProt: Q07889 |
Catalog # | MBS217406 |
Price | $300 |
Order / More Info | SOS1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |