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Antigenic Specificity | SFPQ |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: SFPQ antibody detects endogenous levels of SFPQ. Function: DNA-and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inc |
Immunogen | Immunogen: A synthesized peptide derived from human SFPQ. Subcellular Location: Nucleus Matrix. Predominantly in nuclear matrix. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%) |
Other Names | [100 kDa DNA pairing protein; 100 kDa DNA-pairing protein; 100 kDa subunit; DNA binding p52/p100 complex 100 kDa subunit; DNA-binding p52/p100 complex; hPOMp100; Polypyrimidine tract binding protein associated splicing factor; Polypyrimidine tract-binding protein-associated-splicing factor; POMP100; PPP1R140; proline-and glutamine-rich; Protein phosphatase 1 regulatory subunit 140; PSF; PTB associated splicing factor; PTB-associated-splicing factor; Sfpq; SFPQ_HUMAN; Splicing factor; Splicing factor proline and glutamine rich; Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); Splicing factor proline/glutamine rich] |
Gene, Accession # | [SFPQ], Gene ID: 6421, NCBI: NP_005057.1, UniProt: P23246 |
Catalog # | MBS9603545 |
Price | $240, $280 |
Order / More Info | SFPQ Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |