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Antigenic Specificity | Granzyme B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total Granzyme B protein. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.David A. Jans, J. Biol. Chem., Nov 1996; 271: 30781.Eugene Estella, Diabetes, Aug 2006; 55: 2212 - 2219.Yong Gu, J. Biol. Chem., May 1996; 271: 10816.Jiuru Sun, J. Biol. Chem., Nov 1996; 271: 27802. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from human Granzyme B. |
Other Names | [3.4.21.79; CCPI; CGL-1; CGL1; CSP-B] |
Gene, Accession # | Gene ID: 3002, NCBI: NP_004122.2, UniProt: P10144 |
Catalog # | MBS9409221 |
Price | $200, $255 |
Order / More Info | Granzyme B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |