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Antigenic Specificity | Mouse CTLA-4 |
Clone | [6G10] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Flow Cytometry (FC/FACS), Neutr |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA-4 is up-regulated rapidly following T cell activation and CD28 ligation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28. |
Immunogen | Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of CTLA-4. |
Other Names | [Ctla4; Cd152; Ly-56; Ctla-4], [Ctla4; Ctla4; Cd152; Ly-56; Ctla-4; Cd152; CTLA-4] |
Gene, Accession # | [CTLA-4], Gene ID: 12477, NCBI: NP_033973.2, UniProt: P09793 |
Catalog # | MBS690911 |
Price | $490 |
Order / More Info | Mouse CTLA-4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |