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Antigenic Specificity | Histone H3 Phospho |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 5 Control Slides, 3 ml (Prediluted), 0.1 mL (Concentrate) |
Concentration | n/a |
Applications | n/a |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Phosphohistone-H3 is one of the five main histone proteins involved in the struc-ture of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucelosomes of the ``beads on a string'' structure. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis. Phosphohistone-H3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in diagnosis of tumor grades, especially in CNS, skin, Gyn., soft tissue, and GIST. |
Immunogen | Immunogen: A synthetic peptide corresponding to Human Histone H3 aa 1-100 (phospho S28) conjugated to Keyhole Limpet Haemocyanin (KLH). Specimen Preparation: Paraffin sections:. The antibody can be used on formalin-fixed paraffin-embedded (FFPE) tissue sections. Ensure tissue undergoes appropriate fixation to ensure best results. Pre-treatment of tissues with heat-induced epitope retrieval (HIER) is recommended using Bio SB ImmunoDNA Retriever with Citrate , ImmunoDNA Retriever with EDTA or Imm |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS373045 |
Price | $130, $150, $170 |
Order / More Info | Histone H3 Phospho Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |