Edit |   |
Antigenic Specificity | PDI |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, dog, hamster, monkey, guinea pig, bovine, sheep, porcine, Xenopus |
Isotype | n/a |
Format | ATTO 390 conjugate |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background Info: Detects ~58kDa Scientific Background: The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation via its oxidase activity and isomerization via its isomerase activity, as well as the reduction of disulphide bonds in proteins (1). Studies suggest BiP and PDI work together sequentially to increase oxidation of these proteins (2, 3). PDI has also been found to function as a chaperone to prevent the aggregation of unfolded substrates, and serves as a subunit of prolyl 4-hydroxylase and microsomal triglyceride transferase (4, 5). PDI is an abundant 5 |
Immunogen | n/a |
Other Names | [PDA2; PDI; PDIA2; PDIP; pancreatic protein disulfide isomerase], [Pdia2; P4hb; Pdip; Pdia1; PDI] |
Gene, Accession # | Gene ID: 287164, NCBI: NP_001099245.2, UniProt: P04785 |
Catalog # | MBS804976 |
Price | $445 |
Order / More Info | PDI Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. NA K.S. et al. (2007) Mol Cells. 24(2): 261-7. 2. Mayer M., Kies U., Kammermeier R., and Buchner J. (2000) J Biol Chem. 275(38): 29421-5. 3. Delom F., Mallet B., Carayon P., and Lejeune P.J. (2001) J Biol Chem 276(24): 21337-42. 4. Schultz-Norton J.R., McDonald W.H., Yates J.R. and Nardulli A.M. (2006) Mol Endocrinol 20(9): 1982-95 5. Turano C., Coppari S. Altieri F. and Ferraro (2002) J Cell Physiol 193: 154-163. 6. Janiszewski M. (2005) J. Biol Chem. 280(49): 40813- 40819. 7. Yoshimori T., et al. (1990) J Biol Chem. 265(26): 15984-90. |