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Antigenic Specificity | CAND1 - middle region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CAND1 |
Other Names | [cullin-associated NEDD8-dissociated protein 1 isoform 1; Cullin-associated NEDD8-dissociated protein 1; cullin-associated NEDD8-dissociated protein 1; cullin associated and neddylation dissociated 1; Cullin-associated and neddylation-dissociated protein 1; TBP-interacting protein of 120 kDa A; TBP-interacting protein 120A; p120 CAND1] |
Gene, Accession # | [CAND1], Gene ID: 55832, NCBI: NP_060918.2, UniProt: Q86VP6 |
Catalog # | MBS3219681 |
Price | $335 |
Order / More Info | CAND1 - middle region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |