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Antigenic Specificity | Rat p75NTR Neurotrophin Receptor |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | rat |
Isotype | IgG1 |
Format | Protein G purified |
Size | 0.05 mL |
Concentration | 1ug/ul |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: 192-IgG reacts with rat p75. It does not cross-react with p75 of human or mouse origin. p75NTR known as a cell surface receptor for NGF, BDNF, NT-3 and NT-4, is also a receptor for b-amyloid, and for the myelin axon repellant protein MAG.1, 2, 4, 6 Binding of neurotrophins induces receptor dimerization followed by phosphorylation of receptor kinase residues and recruitment of intracellular proteins involved in signal transduction. p75NTR functions alone, or in functional complexes with the neurotrophin receptors trkA, trkB and trkC. p75NTR signals via interaction with different transducers such as TRAF6, IRAK, and RIP-2, activating NF-kappaB, JNK and p38, and inactivating rhoA.1, 3, 6 Receptor degradation is mediated by a metal |
Immunogen | Immunogen: Solubilized proteins from PC12 membranes. |
Other Names | n/a |
Gene, Accession # | [NTR] |
Catalog # | MBS4157670 |
Price | $725 |
Order / More Info | Rat p75NTR Neurotrophin Receptor Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |