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Antigenic Specificity | PGP9.5 |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | bovine, human, mouse, porcine, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA, Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers. It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors. |
Immunogen | Immunogen: Native PGP 9.5 protein from brain. |
Other Names | n/a |
Gene, Accession # | [PGP9.5], NCBI: AAB46870.1 |
Catalog # | MBS555024 |
Price | $615 |
Order / More Info | PGP9.5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |