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Antigenic Specificity | TP/ECGF1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit polyclonal to TP/ECGF1. Thymidine phosphorylase (TP) is a platelet-derived endothelial cell growth factor (PD-ECGF) that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate (1). This intracellular enzyme is capable of both promoting angiogenesis and inhibiting apoptosis. Thymidine phosphorylase catalytic activity is required for its angiogenic function (2,3). Increased expression of TP/PD-ECGF is seen in a wide variety of different solid tumors and inflammatory diseases and is often associated with poor prognosis (4,5). Alternatively, TP can activate fluorouracil derivative (DFUR) prodrugs and increase the antitumor activity of the related treatment (1,5). The use of thymidine phospho |
Immunogen | Immunogen: A Fusion protein of human TP/ECGF1 |
Other Names | [TYMP; TYMP; ECGF1; MNGIE; PDECGF; TP; hPD-ECGF;], [TYMP; TYMP; TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF; ECGF1; TP; PD-ECGF] |
Gene, Accession # | Gene ID: 1890, NCBI: NP_001107227.1, UniProt: P19971 |
Catalog # | MBS125669 |
Price | $275, $430 |
Order / More Info | TP/ECGF1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Rooseboom, M. et al. (2004) Pharmacol Rev 56, 53-102. 2. Moghaddam, A. and Bicknell, R. (1992) Biochemistry 31, 12141-6. 3. Furukawa, T. et al. (1992) Nature 356, 668. 4. Toi, M. et al. (2005) Lancet Oncol 6, 158-66. 5. Liekens, S. et al. (2007) Biochem Pharmacol 74, 1555-67. |