Edit |   |
---|---|
Antigenic Specificity | LMTK3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: LMTK3 antibody detects endogenous levels of total LMTK3. Function: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).Subunit Structure: Interacts with ESR1 (PubMed:21602804). Interacts with AP-2 complex subunit alpha (By similarity).Similarity: Belongs to the protein kinase superfamily. Tyr protein |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Cell Membrane Predicted Cross Reactivity: Pig, Bovine Similarity: Pig (100%), Bovine (100%) |
Other Names | [BC059845; KIAA1883; Lemur tyrosine kinase 3; LMR3; MGC90743; Serine/threonine-protein kinase LMTK3; TYKLM3] |
Gene, Accession # | [LMTK3], Gene ID: 114783, NCBI: Q96Q04.2, UniProt: Q96Q04 |
Catalog # | MBS9604865 |
Price | $240, $280 |
Order / More Info | LMTK3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |