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Antigenic Specificity | TrkC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This TrkC antibody is generated from rabbits immunized with a his tag recombinant protein of human TrkC. TRKC, a member of the insuline receptor subfamily of Tyr protein kinases, is a receptor for neurotrophin-3 (NT-3). Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats. |
Immunogen | n/a |
Other Names | [NT-3 growth factor receptor; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; NTRK3; TRKC] |
Gene, Accession # | [NTRK3], Gene ID: 4916, NCBI: NP_001012338.1, UniProt: Q16288 |
Catalog # | MBS9213506 |
Price | $165, $370 |
Order / More Info | TrkC Antibody from MYBIOSOURCE INC. |
Product Specific References | McGregor, L.M., et al., Genomics 22(2):267-272 (1994). Shelton, D.L., et al., J. Neurosci. 15 (1 Pt 2), 477-491 (1995). |