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Antigenic Specificity | DARC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DARC Antibody: DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor |
Immunogen | Immunogen: DARC antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human DARC. Buffer: DARC Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [DARC; FY; Dfy; GPD; GpFy; ACKR1; CCBP1; CD234; WBCQ1; FY; Atypical chemokine receptor 1; Duffy blood group, chemokine receptor], [ACKR1; ACKR1; FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1; DARC; FY; GPD; GpFy] |
Gene, Accession # | [DARC], Gene ID: 2532, NCBI: Q16570.3, UniProt: Q16570 |
Catalog # | MBS150798 |
Price | $375 |
Order / More Info | DARC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |