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Antigenic Specificity | Beta-secretase 2 (CT) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Accumulation of the amyloid- (A) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer?s disease. A peptide is generated by proteolytic cleavage of the amyloid protein precursor (APP) at - and -sites by proteases. The long-sought secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2)1-4. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 14-9. BACE2 also cleaves APP at -site and at a different site within A 8. BACE2 locates on chromosome 21q22.3, the so-called ?Down critical region?, suggesting that BACE2 and A may also contribute to the pathogenesis of |
Immunogen | Immunogen: Synthetic peptide corresponding to amino acids 496 to 511 of human BACE2 |
Other Names | [AEPLC; ALP56; ASP21; Rabbit site APP (Amyloid precursor protein) Cleaving Enzyme-2 (C-Terminal),], [BACE2; BACE2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; AEPLC; ALP56; ASP21; ASP1; Asp 1; Beta-site APP cleaving enzyme 2; DRAP] |
Gene, Accession # | Gene ID: 25825, NCBI: NP_036237.2, UniProt: Q9Y5Z0 |
Catalog # | MBS395579 |
Price | $510 |
Order / More Info | Beta-secretase 2 (CT) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |