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Antigenic Specificity | BACE |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | ion exchange purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspa |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a peptide corresponding to 17 amino acids at the carboxy terminus of human BACE. |
Other Names | [Asp] |
Gene, Accession # | [BACE], Gene ID: 23621, NCBI: AF190725 |
Catalog # | MBS9410174 |
Price | $320 |
Order / More Info | BACE Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |