Edit |   |
---|---|
Antigenic Specificity | Human VEGFR-2/KDR |
Clone | [IgG1; EWC] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody will detect native human VEGFR-2/KDR in ELISA experiments and on the surface of different human cell types. VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D |
Immunogen | Immunogen: recombinant human soluble KDR (D7) (RT# S01-002)recombinant human soluble KDR (D7) (RT# S01-002) |
Other Names | [human VEGFR-2/KDR (#EWC); Vascular endothelial growth factor receptor 2], [KDR; KDR; FLK1; CD309; VEGFR; VEGFR2; FLK1; VEGFR2; VEGFR-2; FLK-1; KDR] |
Gene, Accession # | [VEGFR-2/KDR], Gene ID: 3791, NCBI: NP_002241.1, UniProt: P22333 |
Catalog # | MBS690191 |
Price | $365 |
Order / More Info | Human VEGFR-2/KDR Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Shibata et al, BMC Medicine 8 (2010) 2. Albaquerque et al, Nature Med 2009 3. Ebos et al, Mol Cancer Res 2 (2004) 4. Ebos et al, Cancer res 68 (2008). |