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Antigenic Specificity | Human CD35 |
Clone | [AR2] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | fluorescein (FITC) conjugate |
Size | 100 tests |
Concentration | Titered for flow cytometry when used as indicated below. PBMc: Add 10 ul of MAB/10^6 PBMc in 100 ul PBS. Mix gently and incubate for 15 minutes at 2 degree to 8 degree c. Wash twice with PBS and analyze or fix with 0.5% v/v of paraformaldehyde in PBS a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Complement Receptor-1 (CR-1), CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. It is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CR-1 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils. |
Immunogen | Immunogen: CD35=Derived from the hybridization od mouse SP2/0 cells with spleen cells of mice immunized with purified CR1 |
Other Names | [CD35 FITC], [CR1; CR1; KN; C3BR; C4BR; CD35; C3BR] |
Gene, Accession # | [CD35], Gene ID: 1378, NCBI: NP_000642.3, UniProt: P17927 |
Catalog # | MBS397657 |
Price | $255 |
Order / More Info | Human CD35 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Differential effects of the stimulation of complement receptors CR1 (CD35) and CR2 (CD21) on cell proliferation and intracellular Ca2 mobilization of chronic lymphocytic leukemia B cells. Hivroz C; Fischer E; Kazatchkine MD; Grillot-Courvalin C J Immunol 1991 Mar 1;146(6):1766-72 2. The C3b/C4b receptor is recognized by the Knops, McCoy, Swain-langley, and York blood group antisera. Moulds JM; Nickells MW; Moulds JJ; Brown MC; Atkinson JP J Exp Med 1991 May ;173(5):1159-63 3. Deduction from Wilms' tumour that glomerular podocytes produce the basement membrane material bearing Goodpasture determinants. Droz D; Diebold N; Jan D; Jaubert F J Pathol 1990 De;162(4):323-7 4. Purification and characterization of IgG immunoconglutinins from patients with systemic lupus erythematosus: implications for a regulatory function. Nilsson B; Ekdahl KN; Svarvare M; Bjel Clin Exp Immunol 1990 No;82(2):262-7 5. Granulocyte-macrophage colony-stimulating factor increases synthesis and expression of CR1 and CR3 by human peripheral blood neutrophils. Neuman E; Huleatt JW; Jack RM J Immunol 1990 Nov 1;145(10):3325-32 6. Expression of CR1 (CD35) mRNA in podocytes from adult and fetal human kidneys. Appay MD; Kazatchkine MD; Levi-Strauss M; Hinglais N; Bariety J Kidney Int 1990 Au;38(2):289-93 7. Complement receptor type 1 (C3b/C4b receptor; CD35) and complement receptor type 2 (C3d/Epstein-Barr virus receptor; CD21). Fearon DT; Ahearn JM Curr Top Microbiol Immunol 1990;153 p83-98 |