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Antigenic Specificity | PTEN (Phospho-Ser380) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunofluorescence (IF), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody detects endogenous human, mouse, and rat PTEN only when phosphorylated at serine 380. Phosphatase and tensin homolog (PTEN) was identified as a tumor suppressor that is mutated in many cancers. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin-like domain as well as a catalytic domain similar to the dual specificity protein tyrosine phosphatases. Unlike most protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol- 3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating Akt/PKB signaling pathway. |
Immunogen | Antigen: Peptide sequence that includes phosphorylation site of serine 380 derived from human PTEN and conjugated to KLH. |
Other Names | n/a |
Gene, Accession # | [PTEN] |
Catalog # | MBS191021 |
Price | $340 |
Order / More Info | PTEN (Phospho-Ser380) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |