Tyrosine-protein kinase receptor TIE1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Tyrosine-protein kinase receptor TIE1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tyrosine kinase with immunoglobulin-like and EGF-like domains 1, TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.1 The receptor tyrosine kinase Tie1 is expressed in both vascular endothelial cells and immature hematopoietic cells.2 TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.3 |
| Immunogen | Immunogen: A synthetic peptide (conjugated with KLH) corresponding to near N-terminal of human TIE-1. |
| Other Names | [Tyrosine-protein kinase receptor TIE1], [TIE1; TIE1; TIE; JTK14; TIE] |
| Gene, Accession # | [TIE1], Gene ID: 7075, NCBI: NP_005415.1, UniProt: P35590 |
| Catalog # | MBS355080 |
| Price | $275 |
| Order / More Info | Tyrosine-protein kinase receptor TIE1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Partanen J, Armstrong E, Makela TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol. Cell. Biol. 12 (4): 1698-707. 2. Rodewald HR, Sato TN. Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells. Oncogene. 1996 Jan 18;12(2):397-404. 3. Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules. Biochem. Biophys. Res. Commun. 371 (3): 475-9. |
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MYBIOSOURCE INC.
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