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Antigenic Specificity | Phospho-GSK3A/GSK3B (Y216 + Y279) |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/be |
Immunogen | Immunogen: A synthesized peptide derived from human Phospho-GSK3A/GSK3B (Y216 Y279) |
Other Names | [Glycogen synthase kinase-3 alpha; GSK-3 alpha; Serine/threonine-protein kinase GSK3A; GSK3A] |
Gene, Accession # | [GSK3A/GSK3B], Gene ID: 2931, NCBI: NP_063937.2, UniProt: P49840 |
Catalog # | MBS7114830 |
Price | $185, $265 |
Order / More Info | Phospho-GSK3A/GSK3B (Y216 + Y279) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |