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Antigenic Specificity | Mouse CD162 |
Clone | [4RA10] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Western Blot (WB), Block (BL), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be |
Immunogen | n/a |
Other Names | [Mouse CD162; P-selectin glycoprotein ligand 1; Selplg; PSGL-1; Selectin P ligand; CD162] |
Gene, Accession # | [CD162], Gene ID: 20345, NCBI: Q62170.2, UniProt: Q62170 |
Catalog # | MBS2553801 |
Price | $110, $140 |
Order / More Info | Mouse CD162 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Borges E, Eytner R, Moll T, et al.Blood. 1997; 90(5):1934-1942. 2. Borges E, Tietz W, Steegmaier M, et al. J Exp Med. 1997; 185(3):573-578. 3. Frenette PS, Denis CV, Weiss L, et al. J Exp Med. 2000; 191(8):1413-1422. |