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Antigenic Specificity | H2AFX (N-term), 1-30 |
Clone | [980CT1.5.5] |
Host Species | Mouse |
Reactive Species | human (predicted reactivity: zebrafish, mouse) |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This H2AFX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human H2AFX. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizi |
Immunogen | n/a |
Other Names | [Histone H2AX; H2a/x; Histone H2AX; H2AFX; H2AX] |
Gene, Accession # | [H2AFX], Gene ID: 3014, NCBI: NP_002096.1, UniProt: P16104 |
Catalog # | MBS9200580 |
Price | $165, $370 |
Order / More Info | H2AFX (N-term), 1-30 Antibody from MYBIOSOURCE INC. |
Product Specific References | Stewart G.S., et al. Nature 421:961-966(2003). Park E.-J., et al. Nucleic Acids Res. 31:6819-6827(2003). Stiff T., et al. Cancer Res. 64:2390-2396(2004). Lukas C., et al. EMBO J. 23:2674-2683(2004). Kurz E.U., et al. J. Biol. Chem. 279:53272-53281(2004). |