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Antigenic Specificity | MEK1/2 (Non- Phosphospecific) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, chicken |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~44/45 kDa of human MEK1 protein without phosphorylation sites of Ser 218/222 or MEK2 (pS222/226). It does not cross react to phospho MEK1/2. This antibody also reacts with mouse and rat, chicken. The other species are not tested. The MEK1 & 2 (MAPKK1/2) are members of tyrosine/threonine protein kinase family that activate the ERK1+2/MAPK enzymes by phosphorylation. MEK 1 + 2 are also activated by dual-phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEKs. The MEK1 & 2 are regulated by phosphorylation by one of the MEK kinases. |
Immunogen | Antigen Preparation: A synthetic peptide surrounding the epitope -SMANS- without phosphorylation of human MEK1/2. This sequence is identical among human, rat, mouse, chicken. |
Other Names | n/a |
Gene, Accession # | [MEK1/2 (paired S218/S222)] |
Catalog # | MBS462073 |
Price | $285 |
Order / More Info | MEK1/2 (Non- Phosphospecific) Antibody from MYBIOSOURCE INC. |
Product Specific References | Ali R. Jazirehi, et al. Inhibition of the Raf-MEK1/2-ERK1/2 Signaling Pathway, Bcl-xL Down-Regulation, and Chemosensitization of Non-Hodgkin's Lymphoma B Cells by Rituximab. CANCER RESEARCH 64, 7117-7126, October 1, 2004 |