Edit |   |
---|---|
Antigenic Specificity | RASGRP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). |
Immunogen | Immunogen: Recombinant protein of human RASGRP1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [CALDAG-GEFI; CALDAG-GEFII; RASGRP; V; hRasGRP1] |
Gene, Accession # | [RASGRP1], Gene ID: 10125, NCBI: NP_001122074.1, UniProt: O95267 |
Catalog # | MBS8535397 |
Price | $300 |
Order / More Info | RASGRP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |