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Antigenic Specificity | CD71 (C-term), 649-677 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This CD71 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from the C-terminal region of human CD71. Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity. A second ligand, th |
Immunogen | n/a |
Other Names | [Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71; Transferrin receptor protein 1; serum form; sTfR; TFRC] |
Gene, Accession # | [TFRC], Gene ID: 7037, NCBI: NP_001121620.1, UniProt: P02786 |
Catalog # | MBS9212244 |
Price | $165, $370 |
Order / More Info | CD71 (C-term), 649-677 Antibody from MYBIOSOURCE INC. |
Product Specific References | Chicz,R.M., et.al., Nature 358 (6389), 764-768 (1992) Hayes,G.R., et.al., Glycobiology 2 (4), 355-359 (1992) |