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Antigenic Specificity | MAPK3 |
Clone | [AT1A2] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b, k |
Format | Protein G purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1mg/ml |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mitogen-activated protein kinase (MAPKs) are a widely conserved family of serine/threonine kinase involved in many cellular programs such as cell proliferation, differentiation, motility, and death. MAPK3 (ERK1) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is on important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 ar |
Immunogen | Immunogen: Recombinant human MAPK3 protein (1-137aa) purified from E. coli |
Other Names | [Mitogen-activated protein kinase 3; ERK1; HS44KDAP; HuMKER1A; P44ERK1; P44MAPK; PRKM3; MAP kinase3; Mitogen-activated protein kinase 3], [MAPK3; MAPK3; ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; ERK1; PRKM3; MAP kinase 3; MAPK 3; ERK-1; p44-MAPK] |
Gene, Accession # | [MAPK3], Gene ID: 5595, NCBI: NP_002737.2, UniProt: P27361 |
Catalog # | MBS200175 |
Price | $240, $315 |
Order / More Info | MAPK3 Antibody from MYBIOSOURCE INC. |
Product Specific References | Meloche S, et al,. Oncogene (2007) 26:3227-39; Raman M, et al,. Oncogene (2007) 26:3100-12; Roberts PJ, et al,. Oncogene (2007) 26:3291-310; Shaul YD, et al,. Seger R. Acta (2007) 1773:1213-26 |