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Antigenic Specificity | PIK3CA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4, 5)P2 (Phosphatidylinositol 4, 5-bisphosphate) to generate phosphatidylinositol 3, 4, 5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential |
Immunogen | Immunogen: Recombinant Human Phosphatidylinositol 4, 5-bisphosphate 3-kinase catalytic subunit alpha isoform protein (1-206AA) |
Other Names | [Phosphatidylinositol 4; 5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4; 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; PIK3CA] |
Gene, Accession # | [PIK3CA], Gene ID: 5290, NCBI: NP_006209.2, UniProt: P42336 |
Catalog # | MBS7105045 |
Price | $160, $235 |
Order / More Info | PIK3CA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |